Sustained release technology is relatively new field and as a consequence, research in the field has been extremely fertile and has produced many discoveries. The matrix system is most often used for a drug-controlled release from a pharmaceutical dosage form. Isoniazid is an antitubercular, with half life of 1.5-4 hours and requires multiple daily doses to maintain adequate plasma concentration. By considering the facts about drug, the present study was aim to formulate and evaluate the sustained release oral matrix tablet by using Isoniazid as a model drug and see the effects of different polymers to prolong the release of drug for extended period of time. Various formulations of sustained release tablets of Isoniazid were developed using various polymers Guargum, Carbopol, Tragacanth Gum and PEG-6000, in different proportion and combinations by direct compression technique, Bulk density, tapped density, compressibility index, and Hausner ratio before being punched as tablets. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and or standard references. Results of in vitro release profile indicated that formulation (F2) was the most promising formulation as the extent of drug release from this formulation was high as compared to other formulations. It was observed that tablets of batch F2 followed the Zero order release profiles. From the above results and discussion it is concluded that formulation of sustained release tablet of Isoniazid containing Guar gum (1.5%), Batch F2 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hour release as it fulfills all the requirements for sustained release.
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